One major difference is that a FF camera produces a depth of field that's around 1.3 stops shallower than an APS-C camera for the same subject & framing.This is most important when you have the aperture as wide as possible, e.g. for portraiture.
50mm f/2.0 and 35mm f/1.4 may have the same ~25mm aperture diameter but 50mm f/2 has 1.5x more (deeper) DOF than 35mm f/1.4. However, Fuji APS-C is enlarged by 1.5x crop factor relative to the FF sensor, making the APS-C sensor 1.5x shallower DOF, which cancels out the deeper DOF of 50mm f/2 lens.
I just love bringing up the APS-C VS Full Frame discussion and in this video, I also talk about smartphone cameras because I know it'll make haters go crazy.
The camera body design for medium format digital cameras has improved a lot. But they are still bigger and bulkier than full frame cameras. And with the extra size comes extra weight. Some medium format cameras still use traditional designs. The Hasselblad 907X 50C is a prime example. But many now look like larger versions of APS-C or full
The difference between full frame and APS-C sensors is their size. The measurement between any two sensors is known as the crop factor. Full frame to APS-C is generally 1.5x (i.e., the full frame sensor is 1.5x larger).
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